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Study of the association between nailfold capillaroscopic changes and serum level of interleukin-17 in rheumatoid: a clue for emerging vaculitis
Egyptian Rheumatology and Rehabilitation volume 43, pages 190–195 (2016)
Abstract
Objectives
The aim of this work was to study nailfold capillaroscopic (NC) abnormalities and serum interleukin-17 (IL-17) level among rheumatoid arthritis (RA) patients and to find whether IL-17 is causally involved in the changes in the capillary vascular bed, such as autoimmune prevasculitic changes.
Patients and methods
The study was conducted on a group of RA Egyptian patients (n=40) who were diagnosed as having RA based on ACR criteria. Those 40 patients were further divided into two groups. Group 1 included RA patients with clinical signs of skin vasculitis and NC changes (n=6). Group 2 included RA patients with no clinical signs of skin vasculitis and no NC changes (n=34). All patients were subjected to demographic data collection, clinical examination, disease activity score 28 calculation, laboratory measurement (including erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, antinuclear antibody, antineutrophil cytoplasmic antibody, anti-cyclic citrullinated peptide, and IL-17) andNCexamination. Inaddition, group 1 (n=6) was further subjected to electrophysiological evaluation using peripheral nerve conduction studies to determine the effect of vasculitis on the peripheral nerves.
Results
IL-17 level and NC changes showed a significant association in RA vasculitis patients.
Conclusion
Elevated levels of serum IL-17 and characteristic NC changes raise their importance in the detection of preclinical rheumatoid vasculitis.
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Koryem, H.K., Tayel, M.Y., Eltawab, S.S. et al. Study of the association between nailfold capillaroscopic changes and serum level of interleukin-17 in rheumatoid: a clue for emerging vaculitis. Egypt Rheumatol Rehabil 43, 190–195 (2016). https://doi.org/10.4103/1110-161X.192254
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DOI: https://doi.org/10.4103/1110-161X.192254