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Egyptian Rheumatology and Rehabilitation
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Study of the association between nailfold capillaroscopic changes and serum level of interleukin-17 in rheumatoid: a clue for emerging vaculitis

Egyptian Rheumatology and Rehabilitation volume 43, pages 190–195 (2016)Cite this article

Abstract

Objectives

The aim of this work was to study nailfold capillaroscopic (NC) abnormalities and serum interleukin-17 (IL-17) level among rheumatoid arthritis (RA) patients and to find whether IL-17 is causally involved in the changes in the capillary vascular bed, such as autoimmune prevasculitic changes.

Patients and methods

The study was conducted on a group of RA Egyptian patients (n=40) who were diagnosed as having RA based on ACR criteria. Those 40 patients were further divided into two groups. Group 1 included RA patients with clinical signs of skin vasculitis and NC changes (n=6). Group 2 included RA patients with no clinical signs of skin vasculitis and no NC changes (n=34). All patients were subjected to demographic data collection, clinical examination, disease activity score 28 calculation, laboratory measurement (including erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, antinuclear antibody, antineutrophil cytoplasmic antibody, anti-cyclic citrullinated peptide, and IL-17) andNCexamination. Inaddition, group 1 (n=6) was further subjected to electrophysiological evaluation using peripheral nerve conduction studies to determine the effect of vasculitis on the peripheral nerves.

Results

IL-17 level and NC changes showed a significant association in RA vasculitis patients.

Conclusion

Elevated levels of serum IL-17 and characteristic NC changes raise their importance in the detection of preclinical rheumatoid vasculitis.

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Author information

Authors and Affiliations

  1. Department of Physical Medicine, Rheumatology and Rehabilitation, Alexandria, Egypt

    H. K. Koryem & S. S. Eltawab

  2. Department of Internal Medicine, Alexandria, Egypt

    M. Y. Tayel

  3. Department of Clinical Pathology, Alexandria, Egypt

    R. F. Moftah

  4. Department of Physical Medicine, Rheumatology and Rehabilitation, New Miami, Alexandria, Egypt

    Omneya E. Elazzay

Authors
  1. H. K. Koryem
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  2. M. Y. Tayel
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  3. S. S. Eltawab
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  4. R. F. Moftah
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  5. Omneya E. Elazzay
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Correspondence to Omneya E. Elazzay.

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Koryem, H.K., Tayel, M.Y., Eltawab, S.S. et al. Study of the association between nailfold capillaroscopic changes and serum level of interleukin-17 in rheumatoid: a clue for emerging vaculitis. Egypt Rheumatol Rehabil 43, 190–195 (2016). https://doi.org/10.4103/1110-161X.192254

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