Fig. 3
From: Apoptosis in lupus nephritis patients: a study of Bcl-2 to assess glomerular and tubular damage
The sites and distribution of the staining of BCL2 in LN classes: ISN/RPS Class II mesangial proliferative LN (a) with granular mesangial deposits for IgG1+(b), and IgM1+(c). BCL2 showed negative staining of glomeruli and focal faint staining of renal tubules (d). ISN/RPS Class II mesangial proliferative LN (e) with granular mesangial deposits for IgG2+ (f), and IgM1+ (g). BCL2 showed negative staining of glomeruli and strong staining of renal tubules (h). ISN/RPS Class III Focal proliferative LN with segmental endocapillary hypercellularity and segmental capillary wall thickening (i) showing granular capillary wall and mesangial deposits for IgG3+ (j), and IgM1+ (k). BCL2 showed segmental strong staining of glomeruli and strong staining of renal tubules (l). ISN/RPS Class IV Diffuse proliferative LN with global endocapillary hypercellularity and wire capillary wall thickening (m) showing granular capillary wall and mesangial deposits for IgG 3+ (n), and IgM3+ (o). BCL2 showed segmental strong staining of glomeruli and strong staining of renal tubules (p). ISN/RPS Class III/V combined Focal proliferative and membranous LN with moderate hypercellularity and global capillary wall thickening (q) showing granular capillary wall and mesangial deposits for IgG3+ (r), and IgM3+ (s). BCL2 showed negative staining of glomeruli and focal strong staining of renal tubules (t). (a, b, c, d, h, l, p, t × 200), (e, f, g, I, j, k, m, n, o, q, r, s × 400)