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Egyptian Rheumatology and Rehabilitation
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The effect of transplantation of adipose-derived stem cells to spinal cord on the recovery of urinary bladder function in patients having spinal cord injuries: a urodynamic study

Egyptian Rheumatology and Rehabilitation volume 45, pages 100–105 (2018)Cite this article

Abstract

Introduction

Stem cells transplantation, as a therapeutic intervention for spinal cord injury (SCI), has been extensively studied by researchers in recent years.

Our study aimed to study the effect of transplantation of adipose-derived stem cells into spinal cord by intrathecal injection on the recovery of urinary bladder function assessed by a urodynamics study in patients having SCIs.

Patients and methods

A total of 69 patients who had cervical incomplete tetraplegia were divided into two groups: group 1 had 37 patients who were treated with adipose-derived stem cells transplanted into spinal cord via intrathecal injection and were assessed by a urodynamic study before stem cell transplantation and then 6 months and 1 year after transplantation, and group 2 had 32 patients who underwent rehabilitation program only and were assessed by a urodynamic study before starting rehabilitation and then 6 months and 1 year after program.

Results

Eight (21.62%) patients benefitted from stem cells transplantation into spinal cord regarding urinary bladder function as assessed by urodynamics in varying degrees, but there was no significant difference between both groups.

Conclusion

Stem cells transplantation is a promising treatment for patients having SCI.

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Authors and Affiliations

  1. Department of Rheumatology, Physical Medicine and Rehabilitation, Al Azhar University, Cairo, Egypt

    Ahmad El Zayat (MD)

  2. Department of Urology, Al Azhar University, Cairo, Egypt

    Yasser Badran

Authors
  1. Ahmad El Zayat
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  2. Yasser Badran
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Correspondence to Ahmad El Zayat.

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El Zayat, A., Badran, Y. The effect of transplantation of adipose-derived stem cells to spinal cord on the recovery of urinary bladder function in patients having spinal cord injuries: a urodynamic study. Egypt Rheumatol Rehabil 45, 100–105 (2018). https://doi.org/10.4103/err.err_8_18

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  • DOI: https://doi.org/10.4103/err.err_8_18

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