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Egyptian Rheumatology and Rehabilitation
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Study of interleukin 33 in rheumatoid arthritis versus osteoarthritis patients

Egyptian Rheumatology and Rehabilitation volume 44, pages 159–163 (2017)Cite this article

Abstract

Aim of the work

To compare the expression of serum interleukin 33 (IL33), a new member of the interleukin1 (IL-1) cytokine family, in rheumatoid arthritis (RA) versus osteoarthritis (OA) patients and to correlate it with clinical, laboratory and radiographic parameters.

Subjects and methods

20 RA and 20 primary knee OA patients. The levels of serum IL-33 were measured by enzyme-linked immunosorbent assay (ELISA) while anticyclic citrullinated peptide (Anti-CCP), rheumatoid factor (RF), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were measured by standard laboratory techniques. Plain x-ray of both hands and wrists were evaluated using the modified Larsen score 1995 (MLS) in RA patients. Knee OA grading was performed according to the Kellgren Lawrence classification. The correlation of IL-33 level with clinical, laboratory and radiological data of RA and OA was analyzed.

Results

Serum IL-33 level was significantly higher in RA than in OA patients (P< 0.001). This level was positively correlated with disease duration, clinical and laboratory markers of disease activity, impaired functional status and radiographic severity in RA while not in OA patients.

Conclusions

These findings support that IL-33 could have an essential proinflammatory role in the pathogenesis of RA and that IL-33 level may be a monitor of disease activity and severity. IL-33 may become therapeutic target for RA.

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Authors and Affiliations

  1. Department of Physical Medicine, Rheumatology and Rehabilitation, Tanta, Egypt

    Aliaa M. Abd El-Aziz Farag, Nagat M. El-Gazzar & Marwa A. Abo El Hawa (MD)

  2. Department of Clinical Pathology, Faculty of Medicine, Tanta University, 33 El-Motasem Street, 3111, Tanta, Egypt

    Mohamed A. Saad Attia

Authors
  1. Aliaa M. Abd El-Aziz Farag
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  2. Nagat M. El-Gazzar
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  3. Marwa A. Abo El Hawa
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  4. Mohamed A. Saad Attia
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Corresponding author

Correspondence to Marwa A. Abo El Hawa.

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Abd El-Aziz Farag, A.M., El-Gazzar, N.M., Abo El Hawa, M.A. et al. Study of interleukin 33 in rheumatoid arthritis versus osteoarthritis patients. Egypt Rheumatol Rehabil 44, 159–163 (2017). https://doi.org/10.4103/err.err_8_17

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  • DOI: https://doi.org/10.4103/err.err_8_17

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