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Egyptian Rheumatology and Rehabilitation
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Role of interleukin-35 in rheumatoid arthritis pathogenesis and its relation to disease activity and joint damage

Egyptian Rheumatology and Rehabilitation volume 46, pages 177–182 (2019)Cite this article

Abstract

Aim

This study aimed to discuss the role of interleukin-35 (IL-35) in the pathogenesis of rheumatoid arthritis (RA) and its relation to disease activity and radiological severity.

Patients and methods

Thirty patients diagnosed with RA were selected from the outpatient clinic and inpatient unit of Physical Medicine, Rheumatology and Rehabilitation Department, Tanta University Hospitals fulfilling the American College of Rheumatology/ European League Against Rheumatism 2010 criteria for the diagnosis of RA, and 20 apparently healthy individuals who were matched in age and sex participated as controls. Patients with other autoimmune diseases, malignancy, or any current infections were excluded. Disease activity score in 28 joints was assessed for all patients. Rheumatoid factor, anticyclic citrullinated peptide, complete blood count, erythrocyte sedimentation rate and C-reactive protein and serum level of IL-35 measured by enzyme-linked immunosorbent assay were evaluated. The degree of joint destruction was assessed by Larsen score.

Results

Of the RA patients, 73.3%showed low serum levels of IL-35 with significant difference compared with controls, and its levels showed negative association with disease activity. IL-35 serum levels were significantly correlated with hemoglobin level, erythrocyte sedimentation rate, C-reactive protein, and rheumatoid factor and not correlated with anticyclic citrullinated peptide antibodies. Also IL-35 serum levels significantly correlated with radiological disease severity were assessed by Larsen score.

Conclusion

IL-35 had an immunoregulatory role in RA pathogenesis as its serum level is significantly low in RA patients and correlated with different parameters of disease activity and radiological severity.

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Authors and Affiliations

  1. Clinical Pathology, Faculty of Medicine, Tanta University, Egypt

    Nahed El-sayed El-sayed Akl, Soheir Mohammed Abd El-Halim & Maaly Mohamed Mabrouk

  2. Physical Medicine, Rheumatology and Rehabilitation Department, Tanta faculty of Medicine, Tanta University, El-Geish street, Tanta, Gharbia, Egypt

    Doaa Shawky Ashkar & Shymaa Ahmed Hablas MD (Lecturer of Rheumatology and Rehabilitation)

Authors
  1. Nahed El-sayed El-sayed Akl
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  2. Soheir Mohammed Abd El-Halim
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  3. Maaly Mohamed Mabrouk
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  4. Doaa Shawky Ashkar
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  5. Shymaa Ahmed Hablas MD
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Correspondence to Shymaa Ahmed Hablas MD.

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Akl, N.Es.Es., El-Halim, S.M.A., Mabrouk, M.M. et al. Role of interleukin-35 in rheumatoid arthritis pathogenesis and its relation to disease activity and joint damage. Egypt Rheumatol Rehabil 46, 177–182 (2019). https://doi.org/10.4103/err.err_37_18

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  • DOI: https://doi.org/10.4103/err.err_37_18

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