- Original article
- Open access
- Published:
Comparison between the roles of musculoskeletal ultrasound and magnetic resonance imaging in detection of joint inflammation and destruction in rheumatoid arthritis
Egyptian Rheumatology and Rehabilitation volume 46, pages 62–69 (2019)
Abstract
Background
Detection of early signs of synovitis and bone erosions by modern radiological techniques such as musculoskeletal ultrasound (US) and MRI has gained a great interest, as early diagnosis and treatment to target for patients of rheumatoid arthritis (RA) has its impact on disease control.
Aim
The aim of the following study is to detect the ability of US compared with M Rl for the early detection of joint synovitis and bone erosion in RA patients.
Patients and methods
Six hundred joints (second to fifth metacarpophalangeal joints and second to fifth proximal interphalangeal joints) were examined in 50 patients with RA diagnosis.
Clinical assessment, noncontrast MRI, US, and conventional radiography were performed for synovitis and bone erosion evaluation.
Results and conclusion
We concluded that both US and MRI had high ability to detect inflamed joints with close agreement but favoring the US, especially with the added value of power Doppler US where it can reflect increased vascularity associated with inflammation and also with higher scores for these affected joints than that shown by MRI. On the other hand, the study has found that although both US and MRI had high ability to detect erosions with close agreement, the MRI favorably had higher scores for joint erosions compared with the scores shown by US.
References
Scher JU. B-cell therapies for rheumatoid arthritis. Bull NYU Hosp Jt Dis 2012; 70:200–203
Fiocco U, Sfriso P, Oliviero F, Pagnin E, Scagliori E, Campana C, et al. Co-stimulatory modulation in rheumatoid arthritis: the role of (CTLA4-lg) abatacept. Autoimmun Rev 2008;8:76–82
Mclnnes IB, Schett G. Mechanisms of disease. The pathogenesis of rheumatoid arthritis. N Engl J Med 2011; 365:2205–2220
Ometto F, Botsios C, Raffeiner B, Sfriso P, Bernardi L, Todesco S, et al. Methods used to assess remission and low disease activity in rheumatoid arthritis. Autoimmun Rev 2010; 9:161–164
Smolen JS, Aletaha D. Activity assessment in rheumatoid arthritis. Curr Opin Rheumatol 2008; 20:306–313
Paulus HE. Defining remission in rheumatoid arthritis: what is it? Does it matter? J Rheumatol 2004; 31:1–4
Tan YK, 0stergaard M, Conaghan PG. Imaging tools in rheumatoid arthritis: ultrasound vs magnetic resonance imaging. Rheumatology (Oxford) 2012; 51(Suppl 7):vii36–vii42
Masic I, Ridjanovic Z, Pandza H, Masic I. Medical informatics. Sarajevo: Avicena; 2010. 416–430
Karim Z, Wakefield RJ, Quinn M, Conaghan PG, Brown AK, Veale DJ, et al. Validation and reproducibility of ultrasonography in the detection of synovitis in the knee: a comparison with arthroscopy and clinical examination. Arthritis Rheum 2004; 50:387–394
Naredo E, Collado P, Cruz A, Palop MJ, Cabero F, Richi P, et al. Longitudinal power Doppler ultrasonographic assessment of joint inflammatory activity in early rheumatoid arthritis: predictive value in disease activity and radiologic progression. Arthritis Rheum 2007; 57:116–124
Hameed B, Pilcher J, Heron C, Kiely PD. The relation between composite ultrasound measures and the DAS28 score, its components and acute phase markers in adult RA. Rheumatology (Oxford) 2008; 47:476–480
Hodgson RJ, O’Connor P, Moots R. MRI of rheumatoid arthritis image quantitation for the assessment of disease activity, progression and response to therapy. Rheumatology (Oxford) 2008; 47:13–21
Benton N, Stewart N.Crabbe J, Robinson E, Yeoman S, McQueen FM.MRI of the wrist in early rheumatoid arthritis can be used to predict functional outcome at 6 years. Ann Rheum Dis 2004; 63:555–561
Prevoo ML, van ’t Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL. Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 1995; 38:44–48
Genant HK, Jiang Y, Peterfy C, Lu Y, Redei J, Countryman PJ. Assessment of rheumatoid arthritis using a modified scoring method on digitized and original radiographs. Arthritis Rheum 1998; 41:1583–1590
Szkudlarek M, Court-Payen M, Jacobsen S, Klarlund M, Thomsen HS, Østergaard M. Interobserver agreement in ultrasonography of the finger and toe joints in rheumatoid arthritis. Arthritis Rheum 2003;48:955–962
Conaghan PG, Emery P, Østergaard M, Keystone EC.Genovese MC, Hsia EC, et al. Assessment by MRI of inflammation and damage in rheumatoid arthritis patients with methotrexate inadequate response receiving golimumab: results of the GO-FORWARD trial. Ann Rheum Dis 2011; 70:1968–1974
Østergaard M, Peterfy C, Conaghan P, McQueen F, Bird P, Ejbjerg B, et al. OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging Studies. Core set of MRI acquisitions, joint pathology definitions, and the OMERACT RA-MRI scoring system. J Rheumatol 2003; 30:1385–1386
Fuchs HA, Brooks RH, Callahan LF, Pincus T. A simplified twenty-eight-joint quantitative articular index in rheumatoid arthritis. Arthritis Rheum 1989; 32:531–537
Brown AK, Conaghan PG, Karim Z, Quinn MA, Ikeda K, Peterfy CG, et al. An explanation forthe apparent dissociation between clinical remission and continued structural deterioration in rheumatoid arthritis. Arthritis Rheum 2008; 58:2958–2967
Brown AK, Quinn MA, Karim Z, Conaghan PG, Peterfy CG, HensorE, et al. Presence of significant synovitis in rheumatoid arthritis patients with disease-modifying antirheumatic drug-induced clinical remission: evidence from an imaging study may explain structural progression. Arthritis Rheum 2006;54:3761–3773
Colebatch AN, Edwards CJ, Ostergaard M, van der Heijde D, Balint PV, D’Agostin MA, et al. EULAR recommendations for the use of imaging of the joints in the clinical management of rheumatoid arthritis. Ann Rheum Dis 2013; 72:804–14
Mitran C, Barbulescu A, Vreju FA, Criveanu C, Rosu A, Ciurea P. Musculoskeletal ultrasound in early rheumatoid arthritis – correlations with disease activity score. Curr Health Sci J 2015;41:213–218
Szkudlarek M, Klarlund M, Narvestad E, Court-Payen M, Strandberg C, Jensen KE, et al. Ultrasonography of the metacarpophalangeal and proximal interphalangeal joints in rheumatoid arthritis: a comparison with magnetic resonance imaging, conventional radiography and clinical examination. Arthritis Res Ther 2006;8:R52
Rahmani M, Chegini H, Najafizadeh SR, Azimi M, Habibollahi P, Shakiba M. Detection of bone erosion in early rheumatoid arthritis: ultrasonography and conventional radiography versus non-contrast magnetic resonance imaging. Clin Rheumatol 2010; 29:883–891
Xiao H, Liu M.Tan L, Liao X, Li Y, Gao J. et al. Value of ultrasonography for diagnosis of synovitis associated with rheumatoid arthritis. Int J Rheum Dis 2014; 17:767–775
Baillet A, Gaujoux-Viala C, Mouterde G, Pham T, Tebib J, Saraux A, et al. Comparison of the efficacy of sonography, magnetic resonance imaging and conventional radiography for the detection of bone erosions in rheumatoid arthritis patients: a systematic review and meta-analysis. Rheumatology (Oxford) 2011; 50:1137–1147
Author information
Authors and Affiliations
Corresponding author
Additional information
This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
Rights and permissions
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Salama, S.M. Comparison between the roles of musculoskeletal ultrasound and magnetic resonance imaging in detection of joint inflammation and destruction in rheumatoid arthritis. Egypt Rheumatol Rehabil 46, 62–69 (2019). https://doi.org/10.4103/1110-161X.247617
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.4103/1110-161X.247617