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Egyptian Rheumatology and Rehabilitation
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Vitamin D receptor gene polymorphism in rheumatoid arthritis and its association with atherosclerosis

Egyptian Rheumatology and Rehabilitation volume 42, pages 145–152 (2015)Cite this article

Abstract

Aim of the work

Determine vitamin D receptor gene BsmI, FokI polymorphism and 25-hydroxyvitamin D in early Egyptian rheumatoid patients and its association to subclinical atherosclerosis.

Patients and methods

This study included forty early rheumatoid arthritis patients and forty healthy controls. Disease activity score 28 (DAS-28), Modified Health Assessment Questionnaire (MHAQ), Carotid intima-media thickness (cIMT) were assessed using B-mode ultrasound, Erythrocyte sedimentation rate (ESR), C reactive protein (CRP), Lipid profile, anti cyclic citrullinated PolyPeptid (anti-CCP), serum interleukin-6, Total serum vitamin D and genotype determination of BsmI, FokI polymorphism and allel frequency were measured.

Results

Vitamin D deficiency was observed in 25% of patients. There was no significant difference between RA patients and controls regarding the distribution of BsmI genotype frequencies and allele. However, a significant difference between rheumatoid arthritis patients and controls regarding the distribution of FokI genotype and allele frequencies was found. In addition, FokI polymorphism and the F allele was significantly associated with RA. anti-CCP, interleukin-6 levels, (cIMT) and vitamin D deficiency were significantly higher in the presence of bb homozygote of BsmI genotypes and FF homozygote of FokI genotypes. A significant negative correlation between 25 hydroxy vitamin D levels with (DAS-28), ESR, (CRP), and IL-6 (P < 0.001). However, there was positive correlation between 25 hydroxyvitamin D levels and HDL-C (P < 0.001).

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Author information

Authors and Affiliations

  1. Department of Physical Medicine, Rheumatology and Rehabilitation, Tanta University, Tanta, Egypt

    Amal M. El-Barbary

  2. Department of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Tanta University, Tanta, Egypt

    Manal Shawky Hussein MD & Elsayed M. Rageh

  3. Department of Clinical Pathology, Tanta University, Tanta, Egypt

    Salwa A. Essa

  4. Department of Radiology, Faculty of Medicine, Tanta University, Tanta, Egypt

    Hossam A. Zaytoun

Authors
  1. Amal M. El-Barbary
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  2. Manal Shawky Hussein MD
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  3. Elsayed M. Rageh
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  4. Salwa A. Essa
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  5. Hossam A. Zaytoun
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Corresponding author

Correspondence to Manal Shawky Hussein MD.

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El-Barbary, A.M., Hussein, M.S., Rageh, E.M. et al. Vitamin D receptor gene polymorphism in rheumatoid arthritis and its association with atherosclerosis. Egypt Rheumatol Rehabil 42, 145–152 (2015). https://doi.org/10.4103/1110-161X.163947

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  • DOI: https://doi.org/10.4103/1110-161X.163947

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