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Egyptian Rheumatology and Rehabilitation
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Effects of interleukin-10 gene polymorphism on clinical diversity and activity of systemic lupus erythematosus

Egyptian Rheumatology and Rehabilitation volume 42, pages 49–54 (2015)Cite this article

Abstract

Aim

This study was carried out to determine the effects of interleukin (IL)-10 gene polymorphism 1082A/G on clinical diversity and activity of systemic lupus erythematosus (SLE), as it was shown to be associated with E26 transcription factor binding site, and to assess IL-10 concentration in SLE patients.

Patients and methods

Blood was drawn from 54 SLE patients and 27 healthy controls for DNA extraction. The single nucleotide polymorphism was identified using the PCR-restriction fragment length polymorphism, and serum sample was collected to assay IL-10 concentration.

Results

There was an increase in IL-10 concentration in SLE total patients (mean 49.5 pg/ml). Mutant allele A (76.9%) was found more frequently in SLE patients compared with allele G (23.1%). Genotype AA (66.7%) was found more frequently, followed by AG (20.4%) and GG (12.9%).

Conclusion

IL-10 concentration was elevated in SLE patients and was shown to be associated with disease activity. IL-10 gene polymorphism is not a strong indicator to show susceptibility of the disease.

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Authors and Affiliations

  1. Department of Rheumatology and Rehabilitation, Zagaig University Hospitals, Sharkia, Egypt

    Ahmad A. Emerah MD

  2. Department of Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt

    Kamal F. Mohamed, Nisreen E. Elbadawy & Mai H. Rashad

Authors
  1. Ahmad A. Emerah MD
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  2. Kamal F. Mohamed
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  3. Nisreen E. Elbadawy
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  4. Mai H. Rashad
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Correspondence to Ahmad A. Emerah MD.

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Emerah, A.A., Mohamed, K.F., Elbadawy, N.E. et al. Effects of interleukin-10 gene polymorphism on clinical diversity and activity of systemic lupus erythematosus. Egypt Rheumatol Rehabil 42, 49–54 (2015). https://doi.org/10.4103/1110-161X.157855

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  • DOI: https://doi.org/10.4103/1110-161X.157855

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