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Egyptian Rheumatology and Rehabilitation
Fig. 2 | Egyptian Rheumatology and Rehabilitation

Fig. 2

From: Efficacy of adipose—derived stromal vascular fraction in treatment of osteoarthritis: an experimental study

Fig. 2

Sagittal Section in rat knee stained with H&E showing comparison between induced arthritis untreated group II and treated group III. A Group II at 1 month showing surface erosions (double headed arrows), loss of chondrocytes' arrangement into usual 4 zones, many lacunae appear having degenerated chondrocyte with small darkly stained nuclei (▲) or without nuclei (curved arrows), areas of chondrocytes' loss (*). Clusters of chondrocytes can be noticed near the articular surface (↑). The tidemark is ill-defined. B Group III at 1 month showing smooth and regular articular surface, viable chondrocytes fill all the lacunae (▲) but organized irregularly. Many isogenous clusters can be noticed (↑). Evident tidemark (↑↑) can be seen. C Group II at 2 months still showed microscopic signs of osteoarthritis with surface irregularities and chondrocytes appear degenerated with shrunken cytoplasm and pyknotic eccentric nuclei (curved arrows). Duplication of the tidemark line (↑), superficial fibrillation (head arrows), and subchondral cysts (*) are clearly seen. D Group III at 2 months showing cartilage regeneration is observed with smooth articular surface. Chondrocytes are rearranged in the four usual zones (SZ), (IZ), (DZ), and (CZ) with tidemark (arrows). (H&E, X400)

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