Correlation of hematological parameters, antibodies and cytokines with disease activity in systemic lupus erythematosus: a cross-sectional study

Egyptian Rheumatology and Rehabilitation

Table 4 Impact of laboratory parameters on SLEDAI (univariate model and multivariate regression analysis)

Model	Univariate analysis				Multivariate analysis
	Non-standard regression coefficient		Standard regression coefficient	p	Non-standard regression coefficient		Standard regression coefficient	p
	B	SE	Beta	p	B	SE	Beta	p
ESR	0.157	0.019	0.542	< 0.001	0.122	0.051	0.394	0.020
CRP	0.077	0.021	0.287	< 0.001	0.000	0.043	− 0.001	0.994
Anti-dsDNA ab	0.041	0.007	0.407	< 0.001	0.010	0.013	0.109	0.463
Anti-nucleosome ab	0.045	0.010	0.443	< 0.001	− 0.014	0.020	− 0.157	0.486
Anti-C1q ab	0.122	0.032	0.382	< 0.001	0.034	0.046	0.108	0.461
C3	− 7.065	1.669	− 0.336	< 0.001	− 1.181	2.622	− 0.065	0.655
Serum MCP-1	0.003	0.001	0.318	< 0.001	0.002	0.001	0.325	0.043
Urinary MCP-1	0.017	0.004	0.431	< 0.001	0.005	0.009	0.071	0.607
NLR	1.598	0.379	0.323	< 0.001	0.380	0.633	0.106	0.551
PLR	0.027	0.007	0.303	< 0.001	− 0.003	0.015	− 0.038	0.848
Constant					5.678	4.104		0.173

SLEDAI Systemic Lupus Erythematosus Disease Activity Index, ESR erythrocyte sedimentation rate, CRP C-reactive protein, anti-dsDNA ab anti-double-stranded deoxyribonucleic acid antibodies, ab antibodies, C3 complement component C3, MCP-1 monocyte-chemoattractant protein-1, NLR neutrophil-to-lymphocyte ratios, PLR platelet-to-lymphocyte ratios, SE standard error
p ≤ 0.05 values were accepted as statistically significant