Functional ability in knee osteoarthritis: role of neuropathic pain and central sensitization

Elsehrawy, Gehad Gamal; Ibrahim, Maha Emad; Elshaarawy, Nashwa Kamel; Hefny, Mohamed Ahmed; A.moneim, Nermeen Hassan

doi:10.1186/s43166-023-00193-x

Egyptian Rheumatology and Rehabilitation

Table 6 Comparison between painDetect groups in relation to different measurement (n = 68)

From: Functional ability in knee osteoarthritis: role of neuropathic pain and central sensitization

	Pain detect			p
	≤ 12 (n = 27)	13 – 18 (n = 15)	≥ 19 (n = 26)	p
Age (years)
Mean ± SD	43.9 ± 11.2	46.5 ± 5.9	50.8 ± 11	0.083
Median (Min. – Max.)	43 (29 – 71)	45 (36 – 57)	51.5 (29 – 70)	0.083
Body mass index (kg/m²)
Mean ± SD	28.7 ± 3.7	30.1 ± 5.2	31.8 ± 5	0.044^*
Median (Min. – Max.)	28 (23 – 37)	30 (26 – 44.5)	30.5 (23 – 40)	0.044^*
KL
1, 2	23 (85.2%)	5 (33.3%)	9 (34.6%)	< 0.001^*
3, 4	4 (14.8%)	10 (66.7%)	17 (65.4%)	< 0.001^*
VAS
Mean ± SD	7.56 ± 1.60	8.67 ± 1.84	8.85 ± 0.92	0.005^*
Median (Min. – Max.)	8 (5 – 10)	10 (6 – 10)	9 (7 – 10)	0.005^*
PPT right knee
Mean ± SD	22.9 ± 7.6	21.1 ± 2.6	20 ± 5.3	0.373
Median (Min. – Max.)	22 (10 – 55)	19 (19 – 25)	20 (10 – 30)	0.373
PPT left knee
Mean ± SD	24 ± 8.5	18 ± 7.3	17 ± 6.2	< 0.001^*
Median (Min. – Max.)	21 (12 – 60)	15 (9 – 30)	20 (5 – 30)	< 0.001^*
PPT right Elbow
Mean ± SD	22.6 ± 5.3	22.3 ± 3.8	18.5 ± 6.2	0.084
Median (Min. – Max.)	22 (13 – 46)	21 (15 – 30)	20 (5 – 26)	0.084
CSI
Mean ± SD	43.6 ± 12.1	58 ± 13.9	60.3 ± 9.7	< 0.001^*
Median (Min. – Max.)	46 (24 – 69)	57 (35 – 80)	58 (48 – 87)	< 0.001^*
Timed up and go
Mean ± SD	18.7 ± 3.7	25.5 ± 4.5	26.4 ± 4.4	< 0.001^*
Median (Min. – Max.)	18 (12 – 27)	27 (16 – 32)	25.5 (17 – 37)	< 0.001^*
CST
Mean ± SD	22.2 ± 4	24.6 ± 8.5	25 ± 4.2	0.017^*
Median (Min. – Max.)	22 (13 – 36)	21 (15 – 50)	25 (19 – 33)	0.017^*
HAD-D
Mean ± SD	11.4 ± 5	16.7 ± 4.6	18.2 ± 3.2	< 0.001^*
Median (Min. – Max.)	11 (4 – 21)	17 (11 – 21)	19.5 (10 – 21)	< 0.001^*
HAD-A
Mean ± SD	13 ± 5	19.1 ± 2	19.5 ± 3.8	< 0.001^*
Median (Min. – Max.)	15 (4 – 21)	19 (15 – 21)	19 (13 – 30)	< 0.001^*
KOOS
Mean ± SD	36.6 ± 9.3	27.9 ± 3.9	22.7 ± 7.9	< 0.001^*
Median (Min. – Max.)	35 (26 – 70)	29 (21 – 37)	25 (11 – 38)	< 0.001^*

SD Standard deviation
p p value for Relation between Pain detect with different measurement
^*Statistically significant at p ≤ 0.05
KL Kellgren-Lawrence grading, VAS Visual Analogue Scale, PPT pressure pain threshold, CST performance-based chair and stand test, DN4 Douleur neuropathique 4, HAD-A Hospital Anxiety score, HAD-D Hospital Depression score, CSI central sensitization inventory, KOOS Knee Injury and Osteoarthritis Outcome Score

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