Table 1 Pivotal individualized preconception assessment needs in pregnancy with lupus

Previous gynecologic and obstetric history

Disease activity status current and within the past 6 months

Frequency and patterns of clinical disease flares

Disease and non-disease related comorbidities

The potential for an acute or chronic decline in renal function should be carefully considered in women with lupus nephritis

Serological profile (including the presence of positive antiphospholipid profile, or positive anti-Ro, anti-La, antiU1 RNP)

Disease damage index

Drug history relative to disease status

Current drug regimen and doses

Stratify individual risk

Tailor individual therapeutic options available for management of flares during pregnancy

Patient and family education and counseling