Table 1 Reasons for discontinuation of methotrexate in patients with rheumatoid arthritis
Reasons | n (%) | Reasons | n (%) |
|---|---|---|---|
Infectious diseases | 154 (20.0) | Improved with biologics | 36 (4.7) |
Malignancy | 109 (14.1) | Patient preference | 33 (4.3) |
Respiratory problemsa | 79 (10.2) | Renal dysfunction | 32 (4.2) |
Liver dysfunction | 62 (8.0) | Older age | 20 (2.6) |
Gastrointestinal disease | 51 (6.6) | Heart failure, pleural effusion, oedema | 19 (2.5) |
Haematological diseaseb | 46 (6.0) | Fever | 12 (1.6) |
Invalidity of methotrexate | 44 (5.7) | Poor compliance | 12 (1.6) |
Rheumatoid arthritis remission | 43 (5.6) | Surgery | 6 (0.8) |
Mucocutaneous disease | 41 (5.3) | Neurological disease | 6 (0.8) |
Wish for pregnancy | 39 (5.1) | Others | 51 (6.5) |