Table 1 Key Clinical Questions for Treat to Target management approach for lupus nephritis
Domains | Key questions |
|---|---|
Targeted patients | Who are the targeted patients? |
What is the classification system for lupus nephritis? | |
Treatment target | What are the targets of lupus nephritis treatment? |
Renal biopsy | What are the indications for a renal biopsy in an SLE patient? |
What is the importance of evaluating biopsies for the extent of activity or chronicity? | |
Lab tests | Which serologic tests are most useful when following a patient with lupus nephritis? |
Treatment of lupus nephritis | What is the first line of therapy for patients with severe lupus nephritis? |
Describe a protocol for using CYC in management of lupus nephritis | |
Describe a protocol for using MMF in management of lupus nephritis | |
Which cytotoxic agents are most frequently used for maintenance therapy in the treatment of lupus nephritis? | |
What is the role of B cell depletion therapy in managing lupus nephritis? | |
What is the role of B cell depletion therapy in managing lupus nephritis? | |
What is the adjunctive therapy used in management of lupus nephritis? | |
Management outcome | Who are the patients with lupus nephritis more likely to progress to end-stage renal disease? |
Management of refractory lupus nephritis | What is the strategy for management of refractory Lupus nephritis? |
Pregnancy and lupus nephritis | What is the approach toward management of lupus nephritis during pregnancy? |
Patient’s education and lifestyle advice | What are the main points to be included in the patients’ education program for Lupus nephritis patients? |
Comorbidities screening | Should people with gout be screened for comorbidities? |
Novel treatments facilitating T2T of lupus nephritis | What are the targeted novel biologic agents that are likely to boost the T2T approach to LN? |