A febrile patient with known or suspected systemic juvenile idiopathic arthritis is classified as having macrophage activation syndrome if the following criteria are met: | |
- Ferritin >684 ng/mL and any two of the following: | |
° Platelet count ≤ 181 × 109/L | |
° Aspartate aminotransferase (AST) > 48 units/L | |
° Triglycerides > 156 mg/dL | |
° Fibrinogen ≤ 360 mg/dL |