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Egyptian Rheumatology and Rehabilitation

Table 1 Key questions used to develop the guideline

From: Egyptian evidence-based consensus on clinical practice guidelines for the diagnosis and treat-to-target management of macrophage activation syndrome in children

1- Early diagnostic tools

2- Diagnostic criteria of MAS with sJIA

3- MAS presentations with different diseases

 - Diagnostic criteria for MAS complicating systemic lupus erythematosus

 - Systemic auto-inflammation

 - Kawasaki disease

4. Differential diagnosis

 - sJIA activity

 - Systemic auto-inflammatory diseases (SAIDS)

 - Kawasaki disease

 - Lupus

 - Infection

5. Treat-to-target strategy

4- Management

 - Prevention

 - First line of management

 - Monitoring and follow-up (clinical and laboratory)

5- Define resistant and irresponsive/severe cases of MAS

6- Management of resistant and severe cases

7- MAS and COVID-19

  1. MAS macrophage activation syndrome, sJIA systemic onset juvenile idiopathic arthritis, SAIDS systemic auto-inflammatory diseases, COVID-19 coronavirus disease of 2019
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