Table 1 Key questions used to develop the guideline

• What is FMF?

• What is the genetic predisposition for FMF?

• How FMF is diagnosed and what is the role of the MEFV gene in the diagnosis of FMF?

• How to classify FMF?

• What are FMF prognosis and complications?

• How could we assess FMF disease activity?

• What is the target of treatment?

Clinical response

Laboratory response

Functional response

• How frequent could we assess the response, toxicity, and compliance to treatment?

• What is the role of colchicine in FMF treatment?

• When and how to modify colchicine dose?

• What are complications that could occur with colchicine?

• Could colchicine be used during pregnancy and breastfeeding?

• How can we deal with colchicine-resistant patients?

• What other medications could be used in the treatment of FMF patient?

• What is the role of biological therapy in FMF management?

• How could we monitor FMF?

• How could we manage amyloidosis complicating FMF?