Table 1 Comparison between the two periods according to different parameters in cases group (n = 65)

CRP

 Mean ± SD

39.7 ± 14.2

10.2 ± 7.3

7.016^*

< 0.001^*

 Median (min.–max.)

35 (15–65)

6 (3–30)

DAS28

 Mean ± SD

4.4 ± 1.2

3.3 ± 1.2

7.163^*

< 0.001^*

 Median (min.–max.)

4.6 (2.7–7.6)

3.2 (1.6–6.8)

 Median (min.–max.)

1 (0–3)

1 (0–3)

ADORA2aRQ

Mean ± SD

3.4 ± 2

4.8 ± 2.7

7.012^*

< 0.001^*

Median (min.–max.)

3 (0.7–8.7)

4.4 (0.9–10.3)

ADORA3RQ

 Mean ± SD

4.3 ± 2.4

6.1 ± 3.4

6.831^*

< 0.001^*

 Median (min.–max.)

4.3 (0.7–9.8)

5.6 (0.7–12.1)