Table 1 Distribution of the studied cases according to different demographic and clinical parameters (n=145)
| Â | No. (%) |
|---|---|
Age at time of the study | |
  <16 | 46 (31.7%) |
  16:40ys | 99 (68.3%) |
Sex | |
  Male | 55 (37.9%) |
  Female | 90 (62.1%) |
Age of onset of symptoms | |
  Median (Min. – Max.) | 16 (1 – 40) |
Age of gene testing | |
  Median (Min. – Max.) | 24 (3 – 64) |
presenting manifestations | |
  Abdominal pain | 104 (71.7%) |
  Fever | 41 (28.3%) |
  Musculoskeletal manifestations | 51 (35.2%) |
  Fever | 3 (2.1%) |
  Headache | 12 (8.3%) |
Neurological manifestations | |
  Disorientation | 3 (2.1%) |
  Syncope | 14 (9.7%) |
  Recurrent meningitis | 14 (9.7%) |
  Vertigo | 33 (22.8%) |
  Tremor | 13 (9%) |
  Cerebrovascular disorders | 1 (0.7%) |
  Ataxia | 5 (3.4%) |
  Headache | 5 (3.4%) |
  Seizures | 18 (12.4%) |
  Pseudotumor cerebri | 13 (9%) |
  Paresthesia | 22 (15.2%) |
  Non -neurological symptoms | 19(23.1) |
Musculoskeletal manifestations | |
Arthralgia | |
  Absent | 5 (3.4%) |
  Low back pain | 29 (20%) |
  Knee joints | 37 (25.5%) |
  Feet joints | 29 (20%) |
  ankles joints | 32 (22.1%) |
  Shoulder joints | 11 (7.6%) |
  Chest pain | 1 (0.7%) |
  Wrist and small hand joints | 13 (9%) |
  Myalgia | 28(19.3%) |
  Protracted febrile myalgia | 1 (0.7%) |
  Lower limb muscles | 14 (9.7%) |
  Upper limb muscles | 10 (6.9%) |
  Upper and lower limb muscles | 3 (2.1%) |
Arthritis | |
  Absent | 84 (57.9%) |
  Knee | 24 (16.6%) |
  Feet joints | 10 (6.9%) |
  Ankle Joints | 12 (8.3%) |
  Wrist and hand | 7 (4.8%) |
Pattern of arthritis | |
  Monoarthritis | 39 (26.9%) |
  Oligoarthritis | 11 (7.6%) |
  Polyarthritis | 11 (7.6%) |
Colchicine dose at diagnosis | |
  0.5:1mg | 28 (19.3%) |
  1.5:3mg | 117 (80.7%) |
Current colchicine dose | |
  0.5:1mg | 20 (13.8%) |
  1.5:3mg | 125 (86.2%) |
Cause of colchicine dose increase | 144 (99.3%) |
  Musculoskeletal manifestations | 46 (31.7%) |
  Abdominal pain | 71 (49%) |
  Increased fever duration | 36 (24.8%) |
Serum Amyloid A | |
  <6 (normal) | 17 (12.1%) |
  >6 (Abnormal) | 123 (87.9%) |
  Median (Min. – Max.) | 36.1 (1.9–215) |