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Table 3 Vital signs, blood tests, radiological finding, ECHO findings, and frequency of positive aPLs in both groups at the time of suspicion of thrombosis

From: Anti-phospholipid antibodies in the setting of thromboembolic events associated with severe COVID-19 pneumonia

Variable

Patients with thrombotic events

(n = 65)

Patients without thrombotic events

(n = 108)

P

Respiratory rate

30(26–34.5)

29(25.25–32)

0.4293

Heart rate(b/m)

110(100–122)

109(100–117.8)

0.2853

Oxygen saturation%

88(80–90)

88(82–90)

0.8343

HGB(g/L),

124.48(22.2)

123.23(23.53)

0.7311

WBCs(109/L)

11.27(7.3–14.4)

9.5(6.8–13.8)

0.2253

Platelet count (109/L

253(187.5–336.5)

256.5(194–339)

0.9093

PTT (s)

34.8(29.6–39.35)

34.3(30.7–38.8)

0.6143

PT (s)

13.4(12.1–14.85)

13.05(12.3–14.6)

0.9433

INR

1.14(0.2)

1.11(0.2559)

0.0851

D-dimer(mg/L)

12.99(6.8–21.9)

3.68(2.05–7.2)

< 0.001*3

CT parenchymal findings no. (%)

 No pulmonary infiltrate

 Bilateral peripheral ground glass

2(3.1)

33(50.8)

50(46.3

50(46.3)

0.1792

 Bilateral peripheral ground glass with consolidation

28(43.1)

8(7.4)

 

 Unilateral peripheral ground glass

2(3.1)

0

 

ECHO no. (%)

 Not done

10(15.4)

17(15.7)

 

 Normal

10(15.4)

19(17.6)

 

 VRV dilatation or dysfunction

 Left ventricular dysfunction

 Pulmonary HTN

25(38.5)

6(9.2)

14(21.5)

19(17.6)

23(21.3)

30(27.8)

0.018*2

Positive aPLs no. (%)

 LAC

30(46.2)

44(40.7)

0.4862

 aCL IgG

 aCL IgM

10(15.4)

4(6.2)

14(13)

5(4.6)

0.6552

0.7302

 aβ2GPI IgG

 aβ2GPI IgM

10(15.4)

6(9.2)

3(2.8)

3(2.8)

0.005*2

0.0822

 Any positive aPLs

35(53.8%)

53 (49%)

0.5432

  1. HGB hemoglobin, WBCs white blood cells, PTT partial thromboplastin time, PT prothrombin time, INR international normalized ratio. CT computerized tomography, ECHO echocardiogram, HTN hypertension, aPLs anti-phospholipid antibodies, LAC lupus anti-coagulant, aCL anti-cardiolipin, aβ2GPI anti-β2 glycoprotein
  2. *P<0.05 (significant value)
  3. 1Independent-sample t test
  4. 2Chi-square test
  5. 3Mann-Whitney test