Predictors of admission to intensive care unit among systemic lupus erythematosus patients: prospective study

Abdelwhab, Shimaa Mostafa; Kotb, Lobna Ismaeil; Sameer, Ghada; Dawa, Ghada

doi:10.1186/s43166-021-00102-0

Egyptian Rheumatology and Rehabilitation

Table 2 Comparison of clinical finding and type of treatment of SLE patients admitted to ICU and others during 1-year follow-up

From: Predictors of admission to intensive care unit among systemic lupus erythematosus patients: prospective study

Items		SLE patients admitted to ICU		SLE patients not admitted to ICU		χ²	P
Age	Mean ± SD	27.95 ± 8.98		30.04 ± 6.64		t = 1.44	0.15
disease duration	Mean ± SD	4.96 ± 2.86		4.06 ± 1.58		MW = 1.18	0.24
		No.	%	No.	%
Sex	Female	18	81.8	73	90.1	f	0.3
Sex	Male	4	18.2	8	9.9	f	0.3
Smoking	Yes	0	0.0	7	8.6	f	0.34
Smoking	No	22	100	74	91.4	f	0.34
Oral ulcer	Yes	1	4.5	20	24.7	4.33	0.04
Oral ulcer	No	21	95.5	61	75.3	4.33	0.04
Seizure	Yes	2	9.1	9	11.1	0.074	0.79
Seizure	No	20	90.9	72	88.9	0.074	0.79
Lupus headache	Yes	7	31.8	8	9.9	6.69	0.01
Lupus headache	No	15	68.2	73	90.1	6.69	0.01
Fever > 38	Yes	7	31.8	10	12.3	4.76	0.029
Fever > 38	No	15	68.2	71	87.7	4.76	0.029
Infections	Yes	5	22.7	1	1.2	14.6	0.0001
Infections	No	17	77.3	80	98.8	14.6	0.0001
Hypertension	Yes	16	72.7	53	65.4	0.42	0.52
Hypertension	No	6	27.3	28	34.6	0.42	0.52
DM	Yes	1	4.5	19	23.5	3.95	0.047
DM	No	21	95.5	62	76.5	3.95	0.047
CVA	Yes	0	0.0	13	16.0	4.77	0.029
CVA	No	22	100.0	68	84.0	4.77	0.029
Renal Failure	Yes	5	22.7	1	1.2	14.6	0.0001
Renal Failure	No	17	77.3	80	98.8	14.6	0.0001
Angina	Yes	0	0.0	21	25.9	7.2	0.007
Angina	No	22	100	60	74.1	7.2	0.007
AMI	Yes	0	0.0	13	16.0	4.04	0.044
AMI	No	22	100	68	84.0	4.04	0.044
CVD	Yes	0	0.0	20	24.7	6.74	0.009
CVD	No	22	100	61	75.3	6.74	0.009
Proteinuria more than 0.5 g	Yes	17	77.3	48	59.3
Proteinuria more than 0.5 g	No	5	22.7	33	40.7	2.4	0.12
Hemolytic anemia	Yes	2	9.1	16	19.8	1.36
Hemolytic anemia	No	20	90.9	65	80.2		0.24
Leukopenia < 4000	Yes	11	50.0	11	13.6
Leukopenia < 4000	No	11	50.0	70	86.4	13.66	0.0001
Thrombocytopenia	Yes	9	40.9	22	27.2
Thrombocytopenia	No	13	59.1	59	72.8	1.55	0.21
Anti-dsDNA	Yes	12	54.5	62	76.5	4.14
Anti-dsDNA	No	10	45.5	19	23.5		0.042
HypoC3	Yes	4	18.2	33	40.7	3.83	0.05
HypoC3	No	18	81.8	48	59.3
HypoC4	Yes	2	9.1	35	43.2	8.75	0.003
HypoC4	No	20	90.9	46	56.8
ESR	Abnormal	21	95.5	54	66.7	7.2	0.007
ESR	Normal	1	4.5	27	33.3	7.2	0.007
CRP	Abnormal	15	68.2	73	90.1	60	0.000001
CRP	Normal	7	31.8	8	9.9	60	0.000001
Serum creatinine	Abnormal	15	68.2	32	39.5	5.7	0.017
Serum creatinine	Normal	7	31.8	49	60.5	5.7	0.017
Red cell cast	Yes	9	40.9	8	9.9	12.09
Red cell cast	No	13	59.1	73	90.1		0.001
RBCs > 5/HPF urine	Yes	9	40.9	7	8.6	19.35	0.0001
RBCs > 5/HPF urine	No	13	59.1	74	91.4
WBCs > 5/HPF urine	Yes	8	36.4	3	3.7	f	0.0001
WBCs > 5/HPF urine	No	14	63.6	78	96.3
Steroid	Yes	22	100.0	51	63.0	11.5	0.001
Steroid	No	0	0.0	30	37.0
Azathioprine	Yes	2	9.1	51	63.0	20.1	0.0001
Azathioprine	No	20	90.9	30	37.0
Cyclophosphamide	Yes	4	18.2	18	22.2	0.17	0.68
Cyclophosphamide	No	18	81.8	63	77.8
Chloroquine	Yes	11	50.0	70	86.4	13.7	0.0001
Chloroquine	No	11	50.0	11	13.6
Mycophenolate mofetil	Yes	8	36.4	12	14.8	5.13	0.023
Mycophenolate mofetil	No	14	63.6	69	85.2
Cyclosporine	Yes	3	13.6	2	2.5	4.7	0.03
Cyclosporine	No	19	86.4	79	97.5
SLEDAI		25 ± 12		16 ± 8		0.002 (S)
SLICC Damage Index		7.5 ± 4.6		3.7 ± 2		0.00004 (S)

f Fisher exact test, χ² chi-square test significant for all items except SLEDAI and SLICC Mann-Whitney test, SLE systemic lupus erythematosus, ICU intensive care unit, DM diabetes mellitus, CVA cerebrovascular accident, AMI acute myocardial infarction, CVD cardiovascular disease, C complement, anti-dsDNA anti-double stranded deoxyribonucleic acid, CRP C-reactive protein, ESR erythrocyte sedimentation rate, RBCs red blood cells, WBCs white blood cells, SLEDAI SLE Disease Activity Index, SLICC Systemic Lupus International Collaborating Clinics Damage Index

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