Toll-like receptor 5 and Toll-like receptor 9 single nucleotide polymorphisms and risk of systemic lupus erythematosus and nephritis in Egyptian patients

Egyptian Rheumatology and Rehabilitation

Table 6 Comparison of genotyping distribution of TLR9 gene SNP rs187084 and TLR5 gene SNP rs5744168 between SLE patients with and without LN

	SLE patients without LN		SLE patients with LN		Chi-square test		OR [95% CI]
	n	%	n	%	X²	P	OR [95% CI]
TLR5-rs5744168 SNP
Co-dominant model
CC	131	95.6	58	92.1
CT	6	4.4	3	4.8
TT	0	0.0	2	3.2	4.421	0.110
Recessive model
CC+CT [R]	137	100.0	61	96.8
TT	0	0	2	3.2	4.393	0.036*	11.18 [0.53–26.34]
Dominant model
CC [R]	131	95.6	58	92.1
CT+TT	6	4.4	5	7.9	1.050	0.305	1.88 [0.55–6.42]
TLR9-rs187084 SNP
Co-dominant model
CC	22	16.1	7	11.1
CT	75	54.7	34	54.0
TT	40	29.2	22	34.9	1.189	0.552
Recessive model
CC+CT [R]	97	70.8	41	65.1
TT	40	29.2	22	34.9	0.661	0.416	1.30 [0.69–2.46]
Dominant model
CC [R]	22	16.1	7	11.1
CT+TT	115	83.9	56	88.9	0.852	0.356	0.64 [0.26–1.58]
TLR9-rs352140 SNP
Co-dominant model
CC	41	29.9	28	44.4
CT	64	46.7	21	33.3
TT	32	23.4	14	22.2	4.479	0.107
Dominant model
CC+CT	105	76.6	49	77.8
TT [R]	32	23.4	14	22.2	0.031	0.859	0.94 [0.46–1.91]
Recessive model
CC	41	29.9	28	44.4
CT+TT [R]	96	70.1	35	55.6	4.023	0.045*	1.87 [1.01–3.47]

The chi-square test is used. P is set significant if ≤ 0.05, significant values are marked by *
TLR Toll-like receptor, SNP Single nucleotide polymorphism, SLE Systemic lupus erythematosus, OR Odds ratio, CI Confidence interval, R Reference genotype, LN lupus nephritis