Toll-like receptor 5 and Toll-like receptor 9 single nucleotide polymorphisms and risk of systemic lupus erythematosus and nephritis in Egyptian patients

Egyptian Rheumatology and Rehabilitation

Table 5 Comparison of allele distribution of TLR9 gene SNP rs187084 and TLR5 gene SNP rs5744168 between SLE patients with and without LN

	SLE patients without LN		SLE patients with LN		Chi-square test		OR [95% CI]
	n	%	n	%	X²	P	OR [95% CI]
TLR5-rs5744168 SNP
C allele [R]	268	97.8	119	94.4
T allele	6	2.2	7	5.6	3.110	0.078	2.63 [0.86–7.99]
TLR9-rs187084 SNP
C allele [R]	119	43.4	48	38.1
T allele	155	56.6	78	61.9	1.010	0.315	1.25 [0.81–1.92]
TLR9-rs352140 SNP
C allele	146	53.3	77	61.1
T allele [R]	128	46.7	49	38.9	2.143	0.143	0.73 [0.47–1.12]

The chi-square test is used. P is set significant if ≤ 0.05
TLR Toll-like receptor, SNP Single nucleotide polymorphism, SLE Systemic lupus erythematosus, OR Odds ratio, CI Confidence interval, R Reference allele, LN lupus nephritis