Toll-like receptor 5 and Toll-like receptor 9 single nucleotide polymorphisms and risk of systemic lupus erythematosus and nephritis in Egyptian patients

Egyptian Rheumatology and Rehabilitation

Table 4 Comparison of genotyping distribution of TLR9 gene SNP rs187084 and TLR5 gene SNP rs5744168 between LN patients and controls

	SLE patients with LN		Controls		Chi-square test		OR [95% CI]
	n	%	n	%	X²	P	OR [95% CI]
TLR5-rs5744168 SNP
Co-dominant model
CC	58	92.1	193	96.5
CT	3	4.8	7	3.5
TT	2	3.2	0	0	6.649	0.036*
Recessive model
CC+CT [R]	61	96.8	200	100
TT	2	3.2	0	0	6.398	0.011*	16.30 [0.77–344.14]
Dominant model
CC [R]	58	92.1	193	96.5
CT+TT	5	7.9	7	3.5	2.165	0.141	2.38 [0.73–7.77]
TLR9-rs187084 SNP
Co-dominant model
CC	7	11.1	38	19
CT	34	54	103	51.5
TT	22	34.9	59	29.5	2.256	0.324
Recessive model
CC+CT [R]	41	65.1	141	70.5
TT	22	34.9	59	29.5	0.660	0.417	1.28 [0.70–2.34]
Dominant model
CC [R]	7	11.1	38	19
CT+TT	56	88.9	162	181	2.102	0.147	1.18 [0.79–4.44]
TLR9-rs352140 SNP
Co-dominant model
CC	28	44.4	44	22.0
CT	21	33.3	107	53.5
TT	14	22.2	49	24.5	12.923	0.002*
Dominant model
CC+CT	49	77.8	151	75.5
TT [R]	14	22.2	49	24.5	0.136	0.712	1.14 [0.58–2.23]
Recessive model
CC	28	44.4	44	22.0
CT+TT [R]	35	55.6	156	78	12.139	<0.001*	5.67 [2.91–11.06]

The chi-square test is used. P is set significant if ≤ 0.05, significant values are marked by *
TLR Toll-like receptor, SNP Single nucleotide polymorphism, LN Lupus nephritis, OR Odds ratio, CI Confidence interval, R Reference genotype