Toll-like receptor 5 and Toll-like receptor 9 single nucleotide polymorphisms and risk of systemic lupus erythematosus and nephritis in Egyptian patients

Egyptian Rheumatology and Rehabilitation

Table 3 Comparison of allele distribution of TLR9 gene SNP rs187084 and TLR5 gene SNP rs5744168 between LN patients and controls

	SLE patients with LN		Controls		Chi-square test		OR [95% CI]
	n	%	n	%	X²	P	OR [95% CI]
TLR5-rs5744168 SNP
C allele [R]	119	94.4	393	98.3
T allele	7	5.6	7	1.8	5.356	0.021*	3.30 [1.14–9.60]
TLR9-rs187084 SNP
C allele [R]	48	38.1	179	44.8
T allele	78	61.9	221	55.3	1.73	0.188	1.29 [0.86–1.94]
TLR9-rs352140 SNP
C allele	77	61.1	195	48.8
T allele [R]	49	38.9	205	51.3	5.863	0.015*	1.65 [1.10–2.49]

The chi-square test is used. P is set significant if ≤ 0.05, significant values are marked by *
TLR Toll-like receptor, SNP Single nucleotide polymorphism, LN Lupus nephritis, OR Odds ratio, CI Confidence interval, R Reference allele