Toll-like receptor 5 and Toll-like receptor 9 single nucleotide polymorphisms and risk of systemic lupus erythematosus and nephritis in Egyptian patients

Egyptian Rheumatology and Rehabilitation

Table 2 Comparison of genotyping distribution of TLR9 gene SNP rs187084 and TLR5 gene SNP rs5744168 between SLE patients and controls

	SLE patients		Controls		Chi-square test		OR [95% CI]
	n	%	n	%	X²	P	OR [95% CI]
TLR5-rs5744168 SNP
Co-dominant model
CC	189	94.5	193	96.5
CT	9	4.5	7	3.5
TT	2	1	0	0	2.292	0.318
Recessive model
CC+CT [R]	198	99	200	100
TT	2	1	0	0	2.010	0.156	5.05 [0.24–105.87]
Dominant model
CC [R]	189	94.5	193	96.5
CT+TT	11	5.5	7	3.5	0.931	0.335	1.60 [0.61–4.23]
TLR9-rs187084 SNP
Co-dominant model
CC	29	14.5	38	19
CT	109	54.5	103	51.5
TT	62	31	59	29.5	1.453	0.484
Recessive model
CC+CT [R]	138	69	141	70.5
TT	62	31	59	29.5	0.107	0.744	1.07 [0.70–1.65]
Dominant model
CC [R]	29	14.5	38	19
CT+TT	171	85.5	162	81	1.452	0.228	1.38 [0.82–2.35]
TLR9-rs352140 SNP
Co-dominant model
CC	69	34.5	44	22.0
CT	85	42.5	107	53.5
TT	46	23.0	49	24.5	8.147	0.017*
Dominant model
CC+CT	154	77.0	151	75.5
TT [R]	46	23.0	49	24.5	0.124	0.725	1.09 [0.69–1.72]
Recessive model
CC	69	34.5	44	22.0
CT+TT [R]	131	65.5	156	78.0	7.709	0.005*	1.87 [1.20–2.91]

The chi-square test is used. P is set significant if ≤ 0.05, significant values are marked by *
TLR Toll-like receptor, SNP Single nucleotide polymorphism, SLE Systemic lupus erythematosus, OR Odds ratio, CI Confidence interval, R Reference genotype