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Table 6 Correlations of the serum and synovial IL-37 levels with clinical and laboratory characteristics of the RA patients

From: Interleukin-37 as an anti-inflammatory cytokine: does its relation to disease activity suggest its potential role in rheumatoid arthritis therapy?

 

Serum IL-37

Synovial IL-37

r

P

r

P

Age

− 0.13

0.34

− 0.06

0.72

Disease duration

0.25

0.06

0.34

0.06

Tender joint count

0.83

< 0.001*

0.82

< 0.001*

Swollen joint count

0.72

< 0.001*

0.60

0.0004*

VAS

0.82

< 0.001*

0.82

< 0.001*

ESR (mm/1st h)

0.75

< 0.001*

0.65

< 0.001*

CRP (mg/dl)

0.93

< 0.001*

0.79

< 0.001*

RF (IU/ml)

0.02

0.38

0.28

0.13

Anti-CCP Abs (U/ml)

0.23

0.1

0.02

0.89

DAS-28

0.92

< 0.001*

0.85

< 0.001*

Serum IL-37 (pg/ml)

–

–

0.90

< 0.001*

Synovial IL-37 (pg/ml)

0.90

< 0.001*

–

–

  1. IL-37 interleukin-37, VAS visual analog scale, ESR mm/1st h erythrocyte sedimentation rate of the first hour in milliliter, CRP C-reactive protein, mg/dl milligram per deciliter, RF rheumatoid factor, IU international unit, CCP Abs cyclic citrullinated peptide antibodies, U/ml unit/milliliter, DAS Disease Activity Score, IL-37 interleukin 37, P > 0.05 non-significant, P ≤ 0.05* significant