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Egyptian Rheumatology and Rehabilitation

Table 5 Comparison between the mean serum and synovial IL-37 levels in the RA group according to the medications

From: Interleukin-37 as an anti-inflammatory cytokine: does its relation to disease activity suggest its potential role in rheumatoid arthritis therapy?

IL-37 (mean ± SD)

RA patients on DMARDs (50, 100%)

P

RA patient on bDMARDs (14, 28%)

RA patients on csDMARDs (36, 72%)

Serum IL-37 pg/ml

309.64 ± 45.76

410.97 ± 62.53

< 0.001*

Synovial IL-37 pg/ml

568.33 ± 8.49

632.03 ± 75.28

0.16

DAS-28 score

2.48 ± 0.53

3.95 ± 1.25

0.0001*

  1. RA rheumatoid arthritis, IL-37 interleukin-37, SD standard deviation, bDMARD biological disease-modifying anti-rheumatic drugs, cs conventional synthetic, P ≤ 0.05* significant difference, P> 0.05 non-significant, DAS Disease Activity Score
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