Table 5 Relation between TLR-4 gene variations and age at disease onset, frequency, and duration of attacks before and after colchicine therapy and colchicine dosage
From: Toll-like receptor-4 gene variations in Egyptian children with familial Mediterranean fever
Variable | Negative TLR-4 gene variation (n = 68) | Positive TLR-4 gene variation (n = 2) | P value |
|---|---|---|---|
Age at onset (years) | 4.75 (0.5-12) | 5 (5-5) | 0.750 |
Frequency of attacks per year before colchicine | 4 (1-36) | 6 (4-8) | 0.545 |
Frequency of attacks per year after colchicine | 1 (0-12) | 1 (1-1) | 0.794 |
Duration of attacks before colchicine (h) | 24 (6-72) | 42 (36-48) | 0.459 |
Duration of attacks after colchicine (h) | 6 (0-48) | 15 (6-24) | 0.388 |
Starting dose of colchicine (mg/day) | 1 (0.25-2) | 1.25 (1-1.5) | 0.152 |
Dose of colchicine at time of study (mg/day) | 1 (0.25-2) | 1.75 (1.5-2) | 0.077 |