Egyptian Rheumatology and Rehabilitation

Table 4 Association between FMF genes present in study subjects and FMF disease severity

From: Toll-like receptor-4 gene variations in Egyptian children with familial Mediterranean fever

		Severity of FMF
		Mild		Moderate		Severe		Rank biserial correlation
Variable		N	Row %	N	Row %	N	Row %	Coefficient (r_rb)	P value
FMF gene V627A	Absent	10	19.2%	14	26.9%	28	53.8%	−0.069	0.570
FMF gene V627A	Present	4	22.2%	6	33.3%	8	44.4%	−0.069	0.570
FMF gene E148Q	Absent	11	22.9%	12	25.0%	25	52.1%	0.043	0.726
FMF gene E148Q	Present	3	13.6%	8	36.4%	11	50.0%	0.043	0.726
FMF gene M680I	Absent	9	17.0%	16	30.2%	28	52.8%	−0.099	0.413
FMF gene M680I	Present	5	29.4%	4	23.5%	8	47.1%	−0.099	0.413
FMF gene M694V	Absent	13	21.7%	20	33.3%	27	45.0%	0.253*	0.035
FMF gene M694V	Present	1	10.0%	0	0.0%	9	90.0%	0.253*	0.035
FMF gene M694I	Absent	11	22.0%	13	26.0%	26	52.0%	0.029	0.813
FMF gene M694I	Present	3	15.0%	7	35.0%	10	50.0%	0.029	0.813
FMF gene mutation	Absent	1	50.0%	0	0.0%	1	50.0%	0.069	0.572
FMF gene mutation	Present	13	19.1%	20	29.4%	35	51.5%	0.069	0.572

Data are counts (N) and row percentage (%).
*There is a weak association between FMF gene M694V and severity of FMF (r_rb, 0-253; P value, 0.035)

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