Table 2 Demographic, clinical, and laboratory characteristics of the studied groups regarding age, gender, clinical manifestations, disease severity, and presence of TLR4 gene mutations
From: Toll-like receptor-4 gene variations in Egyptian children with familial Mediterranean fever
Variables | Cases (n = 70) | Controls (n = 50) | P value |
|---|---|---|---|
Age (years), mean ± SD | 9.5 ± 3.5 | 9.4 ± 2.6 | 0.840 |
Gender | |||
 Male n (%) | 30 (42.9%) | 28 (56.0%) | 0.195 |
 Female n (%) | 40 (57.1%) | 22 (44.0%) | |
Clinical manifestations of FMF n (%) | |||
 Abdominal pain | 62 (88.6%) |  |  |
 Recurrent fever | 55 (78.6%) |  |  |
 Arthritis | 55 (78.6%) |  |  |
 Chest pain | 30 (42.9%) |  |  |
 Myalgia | 29 (41.4%) |  |  |
 Skin rash | 4 (5.7%) |  |  |
Degree of disease severity n (%) | |||
 Mild | 14 (20%) |  |  |
 Moderate | 20 (28.6%) |  |  |
 Severe | 26 (51.4%) |  |  |
Laboratory findings | |||
 Positive CRP | 6 (8.6%) |  |  |
 Proteinuria | 1 (1.4%) |  |  |
 Anemia | 1 (1.4%) |  |  |
 Leukocytosis | 4 (5.7%) |  |  |
TLR-4 Asp299Gly genetic variation | |||
 Normal | 69 (98.6%) | 48 (96.0%) | 0.570 |
 Heterozygous | 1 (1.4%) | 2 (4.0%) | |
TLR-4 Thr399Ile genetic variation | |||
 Normal | 69 (98.6%) | 50 (100.0%) | 1.000 |
 Heterozygous | 1 (1.4%) | 0 (0.0%) | |