Significance of serum albumin and derived neutrophil-to-lymphocyte ratio score in assessment of disease activity in rheumatoid arthritis patients

Egyptian Rheumatology and Rehabilitation

Table 2 Correlations between serum albumin, dNLR and albumin-dNLR score with different variables in rheumatoid arthritis patients

Variable	Albumin		dNLR		Albumin-dNLR score
Variable	r	p	r	p	r	p
Age (years)	− 0.14	0.16	0.06	0.54	0.08	0.43
Body mass index (kg/m²)	0.17	0.09	0.04	0.69	0.02	0.87
Disease duration (years)	− 0.09	0.37	0.12	0.23	0.17	0.09
Morning stiffness (min)	− 0.23	0.02	0.49	< 0.001	0.44	< 0.001
Tender joint count	− 0.08	0.41	0.31	0.002	0.39	< 0.001
Swollen joint count	− 0.17	0.09	0.39	< 0.001	0.44	< 0.001
ESR (mm/1st h)	− 0.15	0.15	0.35	< 0.001	0.44	< 0.001
C-reactive protein (mg/l)	− 0.16	0.11	0.33	< 0.001	0.34	< 0.001
Hemoglobin (g/dL)	0.18	0.07	− 0.34	< 0.001	− 0.43	< 0.001
White blood cells (× 10³/ul³)	− 0.04	0.72	0.21	0.03	0.06	0.19
Neutrophils (× 10³/ul³)	− 0.04	0.68	0.52	< 0.001	0.39	< 0.001
dNLR	− 0.002	0.98	–	–	0.45	< 0.001
Platelets (× 10³/ul³)	− 0.06	0.56	0.25	0.01	0.31	0.002
Rheumatoid factor (IU/mL)	0.03	0.74	0.17	0.08	0.07	0.48
Anti-CCP (IU/mL)	0.06	0.56	− 0.004	0.97	0.03	0.79
Albumin (g/dL)	–	–	− 0.002	0.98	− 0.59	< 0.001
Albumin-dNLR score	− 0.59	< 0.001	0.45	< 0.001	–	–
DAS28-ESR	− 0.17	0.09	0.45	< 0.001	0.54	< 0.001
Greyscale	− 0.09	0.37	0.35	< 0.001	0.42	< 0.001
Power Doppler	− 0.17	0.09	0.46	< 0.001	0.43	< 0.001
Total 12 joints US score	− 0.12	0.23	0.4	< 0.001	0.44	< 0.001

ESR erythrocyte sedimentation rate, dNLR derived neutrophil-to-lymphocyte ratio, Anti-CCP Anti-cyclic citrullinated peptide, DAS disease activity score, US ultrasound, NSAIDs nonsteroidal anti-inflammatory drugs. Bold values refers to significance at p < 0.05.