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Table 5 Quality of life and serum βNGF levels in patients with neuropathic pain versus those with non-neuropathic pain

From: Neuropathic pain in primary knee osteoarthritis patients: correlation with physical function, quality of life, disease severity, and serum beta nerve growth factor levels

 

DN4

LANSS

DN4 ≥ 4 (n=37)

DN4 ≤ 3 (n=33)

t

P value

LANSS > 12 (n=27)

LANSS < 12 (n=43)

t

P value

Normalized physical activity OAKHQOL (0 to 100)

51.35±19.12 (0–100)

48.84±19.91 (0–100)

0.537

0.593

47.47±19.05 (0–100)

51.87±19.63 (0–100)

−0.923

0.359

Normalized mental health OAKHQOL (0 to 100)

55.04±23.47 (0–100)

53.63±22.54 (0–100)

0.256

0.799

47.64±24.35 (0–100)

58.6±21.1 (0–100)

−1.992

0.06

Normalized pain OAKHQOL (0 to 100)

38.05±20.33 (0–100)

51.05±24.63 (0–100)

−2.418

0.018*

42.88±21.06 (0–100)

44.99±24.71 (0–100)

−0.368

0.714

Normalized Social support OAKHQOL (0 to 100)

37.84±20.82 (0–100)

43.87±27.3 (4.76–100)

−1.046

0.299

33.69±23.33 (0–100)

45.07±23.79 (0–100)

−1.963

0.054

Normalized Social functioning OAKHQOL (0 to 100)

48.65±21.19 (0–100)

52.94±23.02 (0–100)

−0.812

0.419

47.06±22.31 (0–82.35)

52.94±21.78 (0–100)

−1.09

0.28

Normalized Total OAKHQOL (0 to 100)

45.36±20.39 (0–100)

46.74±20.19 (0–100)

−0.284

0.777

41.16±19.99 (0–100)

49.05±19.89 (0–100)

−1.612

0.112

Serum βNGF (pg/ml)

661.3±246.3 (203–1083)

511.57±220.8 (200–528)

4.852

0.01*

693.9±260.5 (200–1083)

525.9±212.8 (200–600)

2.9

0.004*

  1. Values are labeled as mean ± SD (range). OAKHQOL osteoarthritis knee hip quality of life, DN4 Douleur Neuropathique 4, LANSS Leeds assessment neuropathic symptoms and signs, βNGF serum beta nerve growth factor
  2. *Significant P value ≤ 0.05