Evaluation of serum14-3-3η protein and Sema3A levels in rheumatoid arthritis: diagnostic and prognostic value

Egyptian Rheumatology and Rehabilitation

Table 3 Correlation between the two markers and different parameters in patients group (n = 45)

	Serum 14-3-3η		Serum Sema3A
	r_s	p	r_s	p
Age (years)	− 0.040	0.792	0.103	0.500
Duration of the disease (months)	0.184	0.227	− 0.372^*	0.012^*
DAS 28	0.358	0.06	− 0.703^*	< 0.001^*
ESR	0.237	0.117	− 0.535^*	< 0.001^*
ACPA	0.474^*	0.001^*	− 0.787^*	< 0.001^*
RF	0.374^*	0.011^*	− 0.645^*	< 0.001^*
CRP	0.307	0.065	− 0.668^*	< 0.001^*
SDAI	0.485^*	0.001^*	− 0.581^*	< 0.001^*
SYNOVITIS	0.665^*	< 0.001^*	− 0.501^*	< 0.001^*
Erosions	0.864^*	< 0.001^*	− 0.652^*	< 0.001^*

Serum14-3-3η protein levels: There were positive significant correlations with SDAI (r = 0.485, P = 0.001*), SYNOVITIS (r = 0.665, P < 0.001*), degree of erosion (r = 0.864, P < 0.001*), RF (r = 0.374, P = 0.011*), and ACPA (r = 0.474, P = 0.001). There were no correlations with ESR, CRP, or DAS score. Serum Sema3A level: There were negative correlations with duration of the disease (r = 0.372, P = 0.012*), disease activity (DAS28 score) (r = − 0.703, P < 0.001*), SDAI (r = − 0.581, P < 0.001*), GSN scale (r = 0.501, P < 0.001*), and degree of erosion (r = 0.652, P < 0.001*). ESR (r = − 0.535, P < 0.001*), RF r = 0.645, P < 0.001*), (CRP r = − 0.668, P < 0.001*), and ACPA (r = − 0.787, P < 0.001*)