Fig. 2

Relation between the gray scale ultrasound scan and Doppler flow signal with Sema3A and 14-3-3η protein levels. a Longitudinal scan of the metacarpophalangeal joints showing synovitis grade 3 with Doppler signal grade1 (low-disease activity score). The 14-3-3η protein level showed an increase up to 0.49 ng/ml (controls 0.14 ng/ml) and Sema3A level showed mild decrease 5.1 ng/ml (controls 6.5 ng/ml). b Longitudinal scan of the radiocarpal and intercarpal joints showing synovitis grade 2 Doppler signal grade 1 (low-disease activity score). Serum 14-3-3ηprotein level is 0.46 ng/ml and Sema3A level is 4.1 ng/ml. c Longitudinal scan of the intercarpal joints showing erosion and grade 2 synovitis and grade 1 Doppler signal (low-disease activity score with erosions). The14-3-3η protein level is 0.5 ng/ml, and Sema3A level is 5.9 ng/ml. d Longitudinal scan of the wrist showing grade 3 synovitis and grade 2 Doppler signal with effusion (moderate disease activity score). The 14-3-3η protein level is 0.61 ng/ml, and Sema3A level is 3.5 ng/ml