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Comparison of two different models of rehabilitation programs following total knee replacement operations

Abstract

Background

Total knee replacement operation (TKR) is the treatment of choice in severe knee osteoarthritis (OA). Rehabilitation post-TKR is still not well studied. The aim of this study was to compare between the high-intensity (HI) rehabilitation program and the low-intensity (LI) rehabilitation program following TKR.

Results

At 1 month following the TKR operations, significant improvements were found in the first group compared to the second group in all the measured parameters except for the knee range of motion (ROM). At 3 and 12 months follow-up periods, there were statistically significant differences between both groups in all the evaluated parameters except for the numeric pain rating scale and the knee ROM.

Conclusions

Both high-intensity and low-intensity rehabilitation programs are effective; however, HI program had superior functional gain and patient-reported outcomes compared to the LI program. Moreover, HI group has a long-term functional gain.

Background

Large joint osteoarthritis (OA) is among the most prevalent diseases causing pain and disability worldwide [1]. The exact etiology and mechanism of developing knee OA are still unknown; however, several factors may increase the risk its occurrence [2]. Knee OA could be induced due to the disturbance of the equilibrium between the cartilage degeneration and regeneration with aging, causing knee joint pain, stiffness, limping, and even deformity. Joint cartilage cannot be regenerated naturally. Delaying the degenerative process is the mainstay of management [3].

Total knee replacement operation (TKR), also known as total knee arthroplasty (TKA), is the treatment of choice in severe knee OA, with failed conservative treatments. The frequency of TKR operations in the USA is anticipated to reach more than three million by 2030 [4]. Although TKR reliably reduces pain and improves self-reported function in patients with end-stage, however, the optimum functional capacity and muscle strength are still hard to regain after surgery, which may subject the patients to future persistence of pain and disability [5].

Following TKR, around 60% decrease in quadriceps strength has been reported, even with early starting of the post-operative rehabilitation [6]. This quadriceps weakness may lead to long-term deficit and impairment of functional performance after TKR surgery [6, 7]. There is a high positive correlation between quadriceps muscle deficits and the continued functional limitations. Hence, interventions are needed to be initiated from the early post-operative phase in order to improve the post-operative quadriceps strength, and this is very important to increase the beneficial outcomes post-TKR [8]. According to Bade and colleagues, most of the current TKR rehabilitation programs are not fully effective in regaining the optimal muscle strength to normal levels [9].

The aim of this study was to assess the clinical outcomes of high-intensity (HI) rehabilitation program compared to a lower intensity (LI) traditional rehabilitation program following TKR.

Methods

This study is a randomized controlled study; it included patients who had undergone unilateral cemented TKR through medial parapatellar approach for primary OA and assigned to have post-discharge rehabilitation. Forty patients were randomly recruited from the outpatient clinic of orthopedic department of a big tertiary hospital between January 2017 and June 2018. They were randomly allocated into two groups, 20 patients each. The first group was assigned to follow a high-intensity (HI) rehabilitation program, and the second group (control) was assigned to follow a conventional low-intensity (LI) rehabilitation program. Randomization was conducted through 1:1 random allocation of subjects to each group. Before the step of randomization, legibility criteria were addressed.

The patients were included, if they aged between 50 and 65 years and scheduled for a unilateral TKR operation for primary knee OA. Epidural anesthesia was used in all patients to reduce post-operative pain and allow early rehabilitation.

Exclusion criteria were the following: concurrent medical diseases that could affect rehabilitation progress (e.g., uncontrolled hypertension, uncontrolled diabetes, marked osteoporosis, morbid obesity, advanced malignancy, neurological disease, and decompensated cardiovascular diseases), advanced contra-lateral knee OA with pain score greater than 4/10 with movement, or other lower extremity conditions that cause functional impairment, pacemaker, epilepsy, concurrent orthopedic intervention during surgery that could interfere with outcomes (e.g., collateral or cruciate ligaments repair), and post-operative complication (e.g., pulmonary embolism, heart attack, knee infection, deep venous thrombosis, and problems with scar healing).

Preoperatively, each patient was evaluated by taking full history, body mass index (BMI), clinical examination of the limb and knee joint, functional performance measures, numeric pain rating scale (NPRS), and the Oxford knee score (OKS) [10].

During the hospital stay, the patient received physiotherapy once daily with routine post-operative protocol by a trained physiotherapist. Both groups had initiated their assigned program just post-hospital discharge, and a specified printed form of a unified home exercise program (HEP) was given to each patient to be performed on a daily basis. This program consisted of exercises designed to regain the strength of the operated limb muscles and to improve its mobility.

Patients of both groups had the following common elements in their rehabilitation programs: the usage of neuromuscular electrical stimulation (NMES) to activate the quadriceps muscle directly, patellofemoral joint mobilization, passive knee range of motion (ROM) exercises, scar mobility, cycling for range of motion, lower extremity flexibility exercises, strengthening exercises for the quadriceps, calf and hamstrings, and functional and gait training.

Large flexible self-adhesive electrodes were placed on quadriceps muscle (proximally and distally on the belly of the muscles while the patient is sitting on a chair with the knee 60° flexion). NMES from the portable electrical stimulator with the following parameters, the amplitude was set to the maximal intensity tolerated by the patient. The stimulator was set to deliver a biphasic current: current frequency 50 Hz, pulse duration 250 μs, ramp-up time 3 s, and on-off ration 6:10. Fifteen repetitions were performed during each session.

Group I patients were assigned to perform HI progressive resistance exercise for the operated lower extremity muscle groups adopted from a previously published study done by Bade and co-workers in [11]. The high intensity program was divided into 4 phases:

Phase 1 (weeks 0–2) consisted of a group of simple exercises like heel slide, squats, active knee and ankle ROM exercises, gait training, and neuromuscular electrical stimulation for quadriceps muscle; the criteria of progression to phase 2 are the ability to complete two sets of the designed exercises with eight repetitions without feeling fatigued with NPRS less than 5 at rest and knee ROM more than 15–80°.

Phase 2 (weeks 0–4) consisted of phase 1 exercises in addition to active straight leg raise, hamstrings and calf muscles stretching, and sit-to-stand exercises; the criteria of progression to phase 2 are ability to completing two sets of the designed exercises with eight repetitions without feeling fatigued with NPRS less than 5 at rest and knee ROM more than 15–90°. Moreover, in this phase, resistive exercises are initiated through weights strapped to the ankle joint. After reaching the optimal ankle weight without inducing any fatigue, we gradually shift the patient to machine resistive and strengthening training.

Phase 3 (week 2–12) consists of progression in the intensity of stage 2 exercises, like single-leg calf press, stair climbing (stepping) exercises, tilt board squats, and wall slides knee flexion. Additionally, in this stage progression in resistive and strengthening exercises as tolerated, NMES is applied if there is still quadriceps inhibition, weakness, and/or pain. The criteria of progression to phase 4 are ability to completing 2 sets of the designed exercises with eight repetitions without feeling fatigued with NPRS less than 3 at rest and knee ROM more than 10–100°.

Finally, stage 4 (week 6–12): during this stage, there was progression of stage 3 exercises program and initiation of eccentric resistive exercises; these eccentric workouts were performed either through some exercises like seated single-leg knee eccentric flexion and extension, eccentric single-leg calf press, agility exercises: side-shuffle, backward walking, or through using of the weight machine.

Group II (control) patients were assigned to follow a standard low-intensity (LI) rehabilitation program [12]. The LI rehabilitation program was similar to the high-intensity program in the first two stages; however, in stage 3, there was a very gradual initiation of strengthening exercises with the same progression criteria of HI program, and in stage 4, there was a progression of strengthening exercises as tolerated without any introduction of eccentric resistive exercises.

Both rehabilitation programs were initiated within 1 week post-hospital discharge. The total number of visits was 24 visits over 12 weeks (twice per week) which were scheduled for both groups. Each training session was planned to last for 45–50 min. Thus, the two groups had similar treatment frequency over these 12 weeks. In both groups, therapy was done by the same physiotherapist who experienced in TKR rehabilitation.

In both groups, exercises were advanced, based on attainment of determined milestones as well as the treatment tolerance. Moreover, the exercises were advanced as scheduled, except if the patient had 2 or more of the following findings: an increase of 2 or more points in the resting NPRS, muscle soreness for two or more hours after the last session, a reduction in knee ROM by 5° or more, an increase in knee joint swelling of 2 cm or more, or decreased walking distance from the last session. Hence, the escalation in the session intensity of the following session was accustomed to allow recovery. Nevertheless, if the only finding was muscle soreness lasting 2 to 24 h, we modified the exercises targeting the sored muscle.

Outcomes

Patients were assessed before the operation and then after 1, 3, and 12 months post-operatively by one investigator, who was blinded of the group assignment. The 12-month assessment period was chosen in order to attain an adequate follow-up period, as patients recovering from TKR usually plateau in both strength and functional gains by 12 months post-operative [13]. The following parameters were used as outcome measures:

  1. 1.

    Numeric pain rating scale (NPRS): Which is an 11-point verbal pain rating scale with zero represented no pain and 10 represented the worst pain imaginable. Patients were asked to rate their resting pain during the past 48 h [14].

  2. 2.

    Knee range of motion (ROM): Active knee ROM was measured using goniometer.

  3. 3.

    Functional performance measures: Measures of functional performance included Stair Climbing Test (SCT), timed up and go test (TUG), and 6-min walk test (6MW). The SCT is used to assess the time (in seconds) needed by the subject to ascend and descend a stair flight (18 cm step height, 12 steps). The SCT is used to test the physical ability to ascend and descend the stairs, in addition to balance and lower limb strength while using a specific number of stair steps [15]. The TUG is used to measure the mobility and short distant walking along with assessing the power. During this test estimates, the time (in seconds) needed to get-up from an armchair, walk 3 m, go around, and come back to sit in the same chair without any assistance except for walking aid if required [16]. The 6MW is used to evaluate the capability to walk for considerably longer distances by assessing the maximal total distance walked by an individual at free speed over 6 min on an on a flat indoor floor [17].

  4. 4.

    Oxford Knee Score (OKS): It was developed to be a simple patient-administered method to evaluate pain and function after TKR operations [10]. OKS includes 12-item patient-reported measure containing questions regarding his pain and function. It consists of a 7-item subscale that measures pain, and 5-item subscale that measures function. Each component involves five potential responses that are scored from zero to 4. The final score ranges between zero (worst score) and 48 (best score) [18].

  5. 5.

    Adherences to therapy:

  1. a)

    Attendance adherence: Attendance at the training sessions was collected by the physical therapist delivering the training in a specified log.

  2. b)

    Home exercise program adherence was recorded via a self-reported exercise log that includes the number of days they did the entire HEP.

  3. c)

    Physical therapist adherence to the specified program: The physiotherapist filled in a detailed sheet in order to register the amount, duration, and type of treatments given. If the therapy was not conducted according to the specified program, it will not be counted.

Statistical analysis

The collected data throughout history, clinical examination, and questionnaires were computerized and statistically analyzed using SPSS program “Statistical Package for Social Science” version 16.0. Suitable statistical tests were chosen and used effectively. The differences were considered statistically significant when p value ≤ 0.05.

Results

No differences were found between the two groups regarding all the evaluated variables at the baseline including age, BMI, functional performance measures, knee range of motion, degree of pain, and OKS score (p > 0.05) as shown in Table 1.

Table 1 Preoperative characteristics of both groups

From Table 2, after 1 month of the TKR operation, we found significant improvements (p ≤ 0.05) in group I patients compared to group II in pain and all the other measured parameters, except for the knee ROM. The HI group performed 10.3 s faster on the SCT (Fig. 1), 4.8 s faster on the TUG (Fig. 2) and walked 46.5 m farther on the 6MW (Fig. 3).

Table 2 Post-operative outcome measures of both groups at 1 month
Fig. 1
figure 1

Stair-climbing test (seconds) in both groups

Fig. 2
figure 2

Timed up and go test (seconds) in both groups

Fig. 3
figure 3

6-min walk distances (meters) in both groups

At 3 months following TKR, the HI group performed 2.5 s faster on the SCT (Fig. 1), 1.5 s faster on the TUG (Fig. 2), and walked 57.5 m farther on the 6MW (Fig. 3), compared to the control group. Moreover, we found a significant improvement in group I compared to group II in the OKS. However, there were no significant differences between groups in the NPRS and knee ROM as shown in Table 3.

Table 3 Post-operative outcome measures of both groups at 3 months

Twelve months following TKR, still, there were statistically significant differences in patients of group I compared to group II in all the evaluated functional and clinical parameters (SCT, TUG, 6MW, OKS). HI group performed 4.2 s faster on the SCT (Fig. 1), 2.7 s faster on the TUG (Fig. 2), and walked 37.5 m farther on the 6MW (Fig. 3), compared to the control group. There were no significant differences between both groups in the NPRS and knee ROM as shown in Table 4.

Table 4 Post-operative outcome measures of both groups after 12 months

Regarding adherence to the specified therapy plan, no statistically significant differences between the two groups were found in either the patients’ adherence to sessions’ attendance and home exercise program or the physical therapist adherence to the assigned program (p > 0.05) (Table 5).

Table 5 Adherence of both the therapist and the patients to the assigned therapy program in both groups

During the follow-up time, only two patients had trivial problems. In the HI group, one patient experienced low back pain after the first rehabilitation session, which was completely relieved with cold application. In the control group, two patients in group I and 3 patients in group II experienced exacerbated knee swelling during the course of rehabilitation, but all were minimal swellings (< 2 cm). However, these conditions did not affect their program.

Discussion

The purpose of this study was to compare between the high-intensity (HI) rehabilitation program and the low-intensity (LI) rehabilitation program following total knee replacement operation.

Until the current time, there are no internationally accepted or widely agreed and implemented clinical protocols existing to reliably determine the optimal rehabilitation following TKR, and there are many debates regarding this issue. Adding to that, the paucity and the heterogeneity of most of the researches that investigated the role of physiotherapy post-TKR [19,20,21,22,23,24].

In the current study, we found at the first month post-operative follow-up a significant improvement of pain in high-intensity exercise group (HI) compared to the low-intensity exercises (LI) group, but no difference was noticed at 3 and 12 months follow-up period. This improvement in pain was surprising, owing to the expected increase of pain with progressive resistive exercises, especially in the post-operative period. However, this could be attributed to the combined effects of implementing both NMES and progressive strengthening exercises to decrease the post-operative quadriceps central activation deficits (CAD), and consequently better quadriceps power and function, which led to improved pain with limb loading and improved functional recovery [25]. The quadriceps muscle plays a crucial role for shock absorption during joint function; thus, its weakness decreases the joint protection capacity and disturbing biomechanics leading to greater pain from the overload and stress on the knee [26]. Moreover, the exercises were accustomed to avoid any muscle soreness or subjective exacerbation of pain. So, the patients have benefited from the progressive increase of their power without exacerbating of pain.

Moreover, the data showed that the high-intensity exercise group had superior functional gain and patient-reported outcomes compared to the low-intensity exercise group at 1 and 3 months follow-up periods. Moreover, the high-intensity exercise group continued to demonstrate this gain at the 12 months follow-up period.

A recent systematic review study which has investigated the effect of different post-discharge physiotherapy program on chronic pain post-TKR; they concluded that there is no evidence that any type of the physiotherapy programs is more superior to another on reducing the intensity of chronic pain post-TKR [27].

Our results were consistent with a randomized controlled study done on 2011 by Bade and co-workers [11], compared with the HI program to a lower intensity rehabilitation program in post-TKR patients. The outcomes of therapy included pain scale, ROM, functional evaluation, and measurements of quadriceps muscle power; they concluded that the HI program leads to better strength (short- and long-term) and functional gains compared to the LI rehabilitation program. Moreover, they concluded that the HI program did not result in knee ROM impairment nor any musculoskeletal injuries.

Similarly, Moffet and colleagues [28] compared the intensive functional rehabilitation (IFR) program to the standard care. They concluded that IFR was effective in improving the functional capability after primary TKR in the first year post-surgery. Their results support our argument that intensive rehabilitation improves function after TKR.

Moreover, Petterson and coworkers [29] in their study have compared the progressive strengthening with conventional rehabilitation, and they revealed that the conventional rehabilitation group had less power and functional gain post-TKR at 12 months. They concluded that progressive quadriceps muscle strengthening, with or without the using of neuromuscular electrical stimulation, had enhanced clinical improvement after TKR. Moreover, they concluded that individuals who do not undertake an intensive rehabilitation program following TKR are clearly at a disadvantage, as the conventional rehabilitation does not yield similar outcomes. Moreover, they concluded that progressive HI rehabilitation program could lead to improved outcomes in this population.

In addition, following knee injury or surgery, the combination of muscle training and neuromuscular electrical stimulation may achieve greater improvement in quadriceps strength when compared with volitional training alone. The effect of the neuromuscular electrical stimulation may be through minimizing quadriceps muscle fibers atrophy after joint damage, thus reducing quadriceps weakness and contradicting the arthrogenic muscular inhibition [30, 31].

In two meta-analyses done to study the effectiveness of post-discharge rehabilitation following TKA, they concluded that following TKA, physiotherapy had induced only short-term improvements in physical function. However, they attributed that to the few numbers of studies used [32, 33].

In contradiction to us, Bade and co-workers in another study conducted on 2017 [34] have concluded from their randomized controlled trial, which also compared the HI program to the LI program after TKR, that no differences were found between the two groups in muscle power, functional gain, and patient-reported outcomes at neither 3 nor 12 months. They attributed the limited efficacy of the HI program than expected to the arthrogenic muscular inhibition of quadriceps muscle in the early post-operative period, which can prevent the quadriceps from being fully activated, hence limits the gain from progressive resistance exercises. Therefore, they recommended future researches to study the level of activation failure and whether the addition of alternative strategies such as neuromuscular electrical stimulation could be more effective in the early post-operative period [34]. Moreover, in consistent with our result, another randomized controlled study has concluded that the using of neuromuscular electrical stimulation has been shown to potentiate the activation of the quadriceps muscle and increase its strength following TKA, even in absence of a supervised physiotherapy program [35].

Both of the following reasons may explain the difference between our results and that of Bade and co-workers [34]. The first potential reason is the use of neuromuscular electrical stimulation in our study to prevent the arthrogenic muscular inhibition of quadriceps muscle in the early post-operative period. The other potential reason is the impact of home exercise program adherence in our study compared to them; as in our study, there was no significant difference between groups, while a significant difference between groups in the adherence to home exercise program was present in their study; (i.e., low-intensity exercises group had completed more home exercise program sessions).

The limitation of the current study is the small number of participants. Moreover, another limitation is that the treating physiotherapist was not be blinded however, proper measures were taken to evade this weakness by blinding both the patients and the assessing physiatrist to the group allocation. Studies with larger number of patients are needed to attain the optimal rehabilitation protocol post-TKR.

Conclusion

The early implementation of a high-intensity rehabilitation program following total knee replacement operations had resulted in greater short- and long-term functional gain compared to the lower intensity rehabilitation program, so it is advisable to be implemented in order to augment the functional outcomes post-TKR surgeries.

Availability of data and materials

The data will be available upon request.

Abbreviations

OA:

Osteoarthritis

TKR:

Total knee replacement

TKA:

Total knee arthroplasty

OKS:

Oxford knee score

HI:

High intensity

LI:

Low intensity

HEP:

Home exercise program

SCT:

Stair climbing test

TUG:

Timed up and go test

6MW:

6-min walk test

NPRS:

Numeric pain rating scale

HEP:

Home exercise program

ROM:

Range of motion

NMES:

Neuromuscular electrical stimulation

BMI:

Body mass index

IFR:

Intensive functional rehabilitation

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Acknowledgements

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This study has no funding sources.

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Authors and Affiliations

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Contributions

All authors have contributed to designing the study, collecting and analyzing, interpretation of data, and preparing and revising the manuscript. Design of the study: RS, SK, AM, and GA. Recruitment of patients: RS, SK, AM, and GA. Data collection: RS, SK, AM, and GA. Randomizing: RS and SK. Assessment: RS, SK, and GA. Statistical analysis and data interpretation: RS, SK, AM, and GA. Manuscript preparation: RS, SK, AM, and GA. Manuscript revision: RS, SK, AM, and GA. All co-authors have approved the final version of the manuscript.

Corresponding author

Correspondence to Sahar S. Khalil.

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The study protocol was approved by the Zagazig University Hospital Ethics Committee with reference number ZU-IRB#6198. The study was conducted in accordance with the ethical standards of Helsinki declaration. Informed written consent has been obtained from all subjects involved in the study prior to participation.

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Zaghlol, R.S., Khalil, S.S., Attia, A.M. et al. Comparison of two different models of rehabilitation programs following total knee replacement operations. Egypt Rheumatol Rehabil 47, 31 (2020). https://doi.org/10.1186/s43166-020-00034-1

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